Oct 30, 2020 · Most important developments on innovative extraction procedures and instrument configurations in terms of selectivity, sensitivity and extraction efficiency of various analytes from complex biological matrices.
Feb 15, 2022 · 1. Introduction. Poor aqueous solubility is a prime factor for failure of several drug candidates in clinical trials despite having good therapeutic activity in animal studies. 1 Likewise, a large set of lead compounds have been discovered in the recent times using techniques such as high throughput screening (HTS), but most of these molecules were found to have insufficient bioavailability
Jun 18, 2021 · In general, two main approaches have been adopted to improve the chemical stability of MOFs: (i) de novo synthesis of MOFs, and (ii) improving stability of existing MOFs. De novo synthesis The de novo synthesis widely relies on the HSAB principle. 26 Carboxylate ligands and high-valent metals are expected to form chemically stable MOFs.
Mar 11, 2023 · Modern science is becoming highly multidisciplinary to promote the innovation of new theories and technologies. Synthetic biology (SB) is one of the fastest-growing and most dynamic
Jan 12, 2020 · Continuously growing demand for plant derived therapeutic molecules obtained in a sustainable and eco-friendly manner favors biotechnological production and development of innovative extraction techniques to obtain phytoconstituents. What is more, improving and optimization of alternative techniques for the isolation of high value natural compounds are issues having both social and economic
Sep 1, 2015 · Amongst all matrices discussed in the present series of reviews, food presents the most diverse and complex composition. Food comprises a group of different matrices rather than a specific matrix. The origin of food, animal or vegetal, gives rise to a universe of components (e.g., proteins, carbohydrates, minerals, and vitamins).
Apr 25, 2023 · Key points. The communication between cells and their extracellular matrix (ECM) is encoded in peptide epitopes of structural and signalling ECM proteins, acting as molecular ‘orchestrators
Jul 31, 2018 · The present Special Issue, “Innovative Extraction Techniques and Hyphenated Instrument Configuration for Complex Matrices Analysis”, aims to collect and to disseminate some of the most significant and recent contributions in the interdisciplinary area of innovative extraction procedures from complex matrices followed by validated analytical meth
Fluorescence-Based Biosensors. Marcin. Ptaszek, in Progress in Molecular Biology and Translational Science, 2013. 2.3.1 Chemical modifications. Improvement of chemical stability and moderate increase in quantum yields of fluorescence have been observed for cyanines with a polymethine chain rigidified by the cyclohexene ring. 31 However, cycloheptamethine derivatives substituted at cyclohexene
Aug 1, 2021 · Pharmaceutical cocrystals are defined as crystals that comprise two or more discrete neutral molecules at a stoichiometric ratio and bond together via noncovalent bond interactions (e.g., hydrogen bonding, van der Waals and π···π stacking interactions), in which at least one of the components is API and the others are pharmaceutically acceptable ingredients 17.
Oct 2, 2019 · In general, two main types of approaches have been adopted to improve the chemical stability of MOFs. One is the de novo synthesis of stable unknown MOFs and the other is to improve the stability of existing MOFs. The chemical stabilities of some representative MOFs are summarized in Table 1 . a RT: room temperature.
Jan 30, 2020 · Rationale: For the characterization of the chemical composition of complex matrices such as tobacco smoke, containing more than 6000 constituents, several analytical approaches have to be combined to increase compound coverage across the chemical space. Furthermore, the identification of unknown molecules requiring the implementation of
Feb 11, 2020 · The standard assumptions that underlie many conceptual and quantitative frameworks do not hold for many complex physical, biological, and social systems. Complex systems science clarifies when and why such assumptions fail and provides alternative frameworks for understanding the properties of complex systems. This review introduces some of the basic principles of complex systems science
Mar 11, 2021 · Nanoencapsulation is a technique based on enclosing a bioactive compound (BAC) in liquid, solid or gaseous states within a matrix or inert material for preserving the coated substance (food or flavor molecules/ingredients). Nanoencapsulation can improve stability of BACs, improving the regulation of their release at physiologically active sites.
resealable septum is required for a sample matrix that aggressively attacks all other materials. Viton offers chemical resistance similar to PTFE along with limited ability to reseal after initial puncture. Viton septa have a high resistance to piercing and due to their high cost are considered to be the septum of last resort when all other
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